Name: Regenerative Medicine of Amarillo
Address: 1934 Civic Circle, Amarillo, 79109, TX
Telephone: (806) 410-6584

ORTHOPEDIC CONDITIONS & SPORTS INJURIES

Orthopedic Conditions & Sports Injuries

Characteristics of mesenchymal stem cells derived from Wharton’s jelly of human umbilical cord and for fabrication of non-scaffold tissue-engineered cartilage

Once cartilage is damaged, it has limited potential for self-repair. Autologous chondrocyte implantation is an effective treatment, but patients may suffer during cartilage harvesting and the donor-site morbidity may accelerate joint degeneration. Using autologous mesenchymal stem cells (MSCs) derived chondrocytes is another selection, while it also causes some injuring. The umbilical cord, an ecto-embryo tissue may be an ideal source of cells, because of its accessibility, abundant resources, painless procedures for harvesting, and lack of ethical issues. MSCs isolated from Wharton’s jelly of human umbilical cord express characteristics of pre-chondrocytes, low immunogenicity and are easy to be obtained with higher purity because there have no hematopoietic cells in Wharton’s jelly, so it may be a new seed cells more suitable for constructing tissue-engineered cartilage.

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Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

This study focuses on stem cell based therapeutics for . cartilage and intervertebral disc (IVD) repair. It concludes that mesenchymal stem cell based therapies offer huge potential to revolutionize the treatment of cartilage defects and IVD degeneration.

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Regeneration of Full‐Thickness Rotator Cuff Tendon Tear After Ultrasound‐Guided Injection With Umbilical Cord Blood‐Derived Mesenchymal Stem Cells in a Rabbit Model

Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, they investigated the therapeuticeffects of ultrasound‐guided human umbilical cord blood (UCB)‐derived mesenchymal stem cell (MSC) injection to regenerate a full‐thickness subscapularis tendon tear in a rabbit model by evaluating the gross morphology and histology of the injected tendon and motion analysis of the rabbit’s activity.

This study concluded that UCB‐derived MSC injection under ultrasound guidance without surgical repair or bioscaffold resulted in the partial healing of full‐thickness rotator cuff tendon tears in a rabbit model. Histology revealed that UCB‐derived MSCs induced regeneration of rotator cuff tendon tears and that the regenerated tissue was predominantly composed of type I collagens. In addition, motion analysis showed better walking capacity after MSC injection than HA or normal saline injection. These results suggest that ultrasound‐guided UCB‐derived MSC injection may be a useful conservative treatment for full‐thickness rotator cuff tendon tear repair.

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Human umbilical cord-derived mesenchymal stem cells reduce monosodium iodoacetate-induced apoptosis in cartilage

Based on the present findings, this study conclude that human umbilical cord mesenchymal stem cells (HUCMSCs) can fulfill mesenchymal stem cell (MSC) characteristics with mesoderm differentiation capability. HUCMSCs can assist monosodium iodoacetate (MIA)-treated mice in regeneration of hyaline cartilage and/or repair of cartilage damage and in ameliorating cartilage apoptosis. These effects can be associated with motor behavioral improvement. Thus, HUCMSCs may be a feasible source for stem cell treatment for Osteoarthritis (OA) cartilage repair.

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Effects of insulin-like growth factor-induced Wharton jelly mesenchymal stem cells toward chondrogenesis in an osteoarthritis model

This study aimed to determine the collagen type II (COL2) and SOX9 expression in interleukin growth factor (IGF-1)-induced Wharton’s Jelly mesenchymal stem cells (WJMSCs) and the level of chondrogenic markers in co-culture IGF1-WJMSCs and IL1β-CHON002 as osteoarthritis (OA) cells model.

The study concluded that the IGF1-induced WJMSCs were capable to enhance chondrogenesis, indicated by increased expression of SOX9 and COL2 and decreased expression of ADAMTS1, ADAMTS5, MMP3, MMP1, and RANKL. These findings can be further used in the osteoarthritis treatment.

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Effect of nicotine on the proliferation and chondrogenic differentiation of the human Wharton’s jelly mesenchymal stem cells

Osteoarthritis (OA) is a chronic joint disease characterized by a progressive and irreversible degeneration of articular cartilage. Among the environmental risk factors of OA, tobacco consumption features prominently, although, there is a great controversy regarding the role of tobacco smoking in OA development. Among the numerous chemicals present in cigarette smoke, nicotine is one of the most physiologically active molecules.

At the concentration used, the study concluded that nicotine had an adverse effect on the proliferation and chondrogenic differentiation of mesenchymal stem cells from the human Wharton’s jelly (hWJ-MSCs).

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Human Wharton’s Jelly Mesenchymal Stem Cells Maintain the Expression of Key Immunomodulatory Molecules When Subjected to Osteogenic, Adipogenic and Chondrogenic Differentiation In Vitro: New Perspectives for Cellular Therapy

This study suggests that after the acquisition of a mature phenotype, Wharton’s jelly mesenchymal stem cell (WJMSCs)-derived cells may maintain their immune privilege. This evidence, which deserves much work to be confirmed in vivo and in other mesenchymal stem cells (MSCs) populations, may provide a formal proof of the good results globally achieved with WJMSCs as cellular therapy vehicle.

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Cartilage Repair in the Knee Using Umbilical Cord Wharton’s Jelly–Derived Mesenchymal Stem Cells Embedded Onto Collagen Scaffolding and Implanted Under Dry Arthroscopy

Cell-based cartilage repair procedures are becoming more widely available and have shown promising potential to treat a wide range of cartilage lesion types and sizes, particularly in the knee joint. This study presents a technique of cartilage repair in the knee using Wharton’s jelly–derived mesenchymal stem cells (MSCs) embedded onto scaffolding and implanted in a minimally invasive fashion using dry arthroscopy.

The ability of these cells to promote chondrogenesis, without eliciting an immunogenic response, makes them an excellent candidate for providing cell-based cartilage repair in an off-the-shelf fashion. Moreover, use of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) for cartilage repair in older patients will address concerns related to MSC number and immunomodulatory capacity with autologous harvest in aging patients, making this technique a promising advancement in the treatment of cartilage injury for this demographic.

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Role of mesenchymal stem cells in osteoarthritis treatment

Without an effective cure, Osteoarthritis (OA) remains a significant clinical burden on our elderly population. The advancement of regenerative medicine and innovative stem cell technology offers a unique opportunity to treat this disease. In this study, they examine OA and the likely resolution with mesenchymal stem cells (MSCs). MSCs have been one of the highlights in stem cell research in recent years. Although the application of MSCs in joint repair is well established, it is particularly exciting about MSCs being used for OA treatment.

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Mesenchymal stem cells for cartilage regeneration in osteoarthritis

In summary, this study shows that mesenchymal stem cells (MSCs) can be employed successfully to treat mild to moderate osteoarthritis (OA) through various ways. They provide alternative treatment options and treatment can start early during progression of OA. The traditional major surgeries used to treat late stages are expensive and come with risks. The less invasive techniques outlined in this review have revealed good outcomes, but the field merits further investigation. Superior outcome was evident with greater quantity of MSCs injected. Allogenic cells from healthy young donors can also be utilized. These findings have further empowered researchers to investigate the potentials of MSCs for tissue engineering and a number of clinical trials are now underway. Most of the emphasis on minimally invasive therapeutic alternatives including intraarticular injections of MSCs, aim to cut out cost and risks of major surgeries.

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1934 Civic Circle

Amarillo, TX 79109

☎ office: (806) 410-6584

☎ seminar: (806)410-6584

✉ drparkerarmc@gmail.co m